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Di Fonzo, 2009: Overview of all reported PARK-FBXO7 patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
No
C
NLD
18
n.a.
Yes
Motor fluctuations
Parkinsonism
Gaze palsy
Spasticity/pyramidal signs
Tremor (any or unspecified)
Postural instability
Saccadic abnormalities
Bradykinesia
Dyskinesia
Behavioral abnormalities
Rigidity
Atypical parkinsonism
Tremor, action
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Tremor (any or unspecified)
Yes
C
NLD
19
n.a.
Yes
Postural instability
Dyskinesia
Motor fluctuations
Tremor (any or unspecified)
Atypical parkinsonism
Tremor, action
Rigidity
Behavioral abnormalities
Parkinsonism
Bradykinesia
Dysphagia
Spasticity/pyramidal signs
Tremor at rest
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Bradykinesia
No
C
ITA
13
n.a.
Yes
Motor fluctuations
Tremor, action
Atypical parkinsonism
Saccadic abnormalities
Behavioral abnormalities
Dysphagia
Bradykinesia
Dyskinesia
Postural instability
Spasticity/pyramidal signs
Dysarthria anarthria
Tremor at rest
Rigidity
Incontinence
Tremor (any or unspecified)
Gaze palsy
Dystonia
Parkinsonism
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Rigidity
Tremor (any or unspecified)
p.Arg498*: het
Yes
C
ITA
10
n.a.
Yes
Parkinsonism
Dystonia
Rigidity
Behavioral abnormalities
Tremor, action
Bradykinesia
Dyskinesia
Tremor (any or unspecified)
Dysarthria anarthria
Atypical parkinsonism
Postural instability
Micrographia
Spasticity/pyramidal signs
Motor fluctuations
Incontinence
Tremor at rest
Dysphagia
Show more (+14)
Tremor (any or unspecified)
p.Arg498*: het