Paisán-Ruiz, 2010: Overview of all reported PARK-FBXO7 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
TUR
|
17
|
n.a.
|
No
|
Diurnal fluctuations
Parkinsonism Hypomimia Bradykinesia Atypical parkinsonism Rigidity Gait difficulties/falls Dysarthria/anarthria NMS parkinsonism Postural instability Dyskinesia Oculogyric spasms Psychotic sign/sympt. Show more (+10) |
Gait difficulties/falls
|
|
No
|
♀
|
n.a.
|
PAK
|
22
|
22
|
n.a.
|
Spasticity/pyramidal signs
Dyskinesia Cognitive decline Dystonia Parkinsonism Postural instability Atypical parkinsonism Psychotic sign/sympt. Bradykinesia Show more (+6) |
Bradykinesia
|
|
No
|
♀
|
n.a.
|
PAK
|
24
|
44
|
n.a.
|
Psychotic sign/sympt.
Postural instability Rigidity Bradykinesia Cognitive decline Cataracts Spasticity/pyramidal signs Respiratory sighs Atypical parkinsonism Dyskinesia Gaze palsy Parkinsonism Show more (+9) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
PAK
|
17
|
22
|
n.a.
|
Cataracts
Dysarthria/anarthria Rigidity Spasticity/pyramidal signs Respiratory sighs Apraxia Psychotic sign/sympt. Dyskinesia Parkinsonism Atypical parkinsonism Cognitive decline Autonomic sign/sympt. Gaze palsy Bradykinesia Postural instability Show more (+12) |
Rigidity
Bradykinesia |