Paisán-Ruiz, 2010: Overview of all reported PARK-FBXO7 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
TUR
|
17
|
n.a.
|
No
|
NMS parkinsonism
Dysarthria/anarthria Parkinsonism Diurnal fluctuations Bradykinesia Gait difficulties/falls Postural instability Oculogyric spasms Psychotic sign/sympt. Atypical parkinsonism Rigidity Dyskinesia Hypomimia Show more (+10) |
Gait difficulties/falls
|
|
No
|
♀
|
n.a.
|
PAK
|
22
|
22
|
n.a.
|
Postural instability
Dystonia Bradykinesia Cognitive decline Parkinsonism Spasticity/pyramidal signs Psychotic sign/sympt. Atypical parkinsonism Dyskinesia Show more (+6) |
Bradykinesia
|
|
No
|
♀
|
n.a.
|
PAK
|
24
|
44
|
n.a.
|
Respiratory sighs
Psychotic sign/sympt. Atypical parkinsonism Bradykinesia Cognitive decline Cataracts Gaze palsy Dyskinesia Postural instability Spasticity/pyramidal signs Parkinsonism Rigidity Show more (+9) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
PAK
|
17
|
22
|
n.a.
|
Psychotic sign/sympt.
Cataracts Respiratory sighs Cognitive decline Spasticity/pyramidal signs Autonomic sign/sympt. Bradykinesia Apraxia Dysarthria/anarthria Postural instability Atypical parkinsonism Rigidity Gaze palsy Dyskinesia Parkinsonism Show more (+12) |
Bradykinesia
Rigidity |