Chelban, 2017: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Peripheral neuropathy on nerve conduction studies
Show more (+1)
n.a.
p.Arg562*: het
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Cognitive impairment
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Central motor conduction time abnormality
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Peripheral neuropathy on nerve conduction studies
Show more (+1)
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Seizures
Cognitive impairment
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Psychosis
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Pes cavus
Spasticity, lower limb
Dystonia (any or unspecified)
n.a.
p.Arg562*: het
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Peripheral neuropathy on nerve conduction studies
Spasticity, lower limb
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Show more (+1)
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Peripheral neuropathy on nerve conduction studies
Spasticity, lower limb
Nerve conduction studies other abnormalities
n.a.