Chelban, 2017: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Peripheral neuropathy on nerve conduction studies
Nerve conduction studies other abnormalities
Central motor conduction time abnormality
Show more (+1)
n.a.
p.Arg562*: het
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Cognitive impairment
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Central motor conduction time abnormality
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Spasticity, lower limb
Peripheral neuropathy on nerve conduction studies
Show more (+1)
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Cognitive impairment
Seizures
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Psychosis
Spasticity, lower limb
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Pes cavus
Dystonia (any or unspecified)
Spasticity, lower limb
n.a.
p.Arg562*: het
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Peripheral neuropathy on nerve conduction studies
Spasticity, lower limb
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Show more (+1)
n.a.
Yes
n.a.
n.a.
GBR
n.a.
n.a.
No
Spasticity, lower limb
Peripheral neuropathy on nerve conduction studies
Nerve conduction studies other abnormalities
n.a.