Lindsey, 2000: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
GBR
|
n.a.
|
11
|
n.a.
|
Impaired vibratory sensation
Impaired temperature sensation Hyperreflexia in upper limbs |
n.a.
|
|
Yes
|
♂
|
n.a.
|
GBR
|
60
|
75
|
n.a.
|
Impaired vibratory sensation
Spastic gait Spasticity, lower limb Pes cavus Abnormality of the bladder Lower limb muscle weakness Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
40
|
70
|
No
|
Pes cavus
Upper limb amyotrophy -Lower limb amyotrophy |
n.a.
|
|
No
|
♀
|
n.a.
|
GBR
|
40
|
86
|
No
|
Wheelchair
Pes cavus Upper limb amyotrophy Spastic gait -Lower limb amyotrophy Cognitive impairment Inability to walk Show more (+4) |
n.a.
|
|
Yes
|
♂
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
n.a.
|
Impaired vibratory sensation
-Lower limb amyotrophy Spasticity, lower limb Impaired pain sensation -Pure or uncomplicated Cognitive impairment Show more (+3) |
n.a.
|