Orlacchio, 2005: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
ITA
25
46
n.a.
Spasticity, lower limb
Impaired vibratory sensation
Babinski sign
Spastic gait
Central motor conduction time abnormality
Pes cavus
Show more (+3)
n.a.
No
C
ITA
23
41
n.a.
Pes cavus
Babinski sign
Spasticity, lower limb
Abnormality of the bladder
Impaired vibratory sensation
Central motor conduction time abnormality
Spastic gait
Show more (+4)
n.a.
No
C
ITA
49
75
n.a.
Wheelchair
Abnormality of the bladder
Nerve conduction studies other abnormalities
Inability to walk
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Babinski sign
Spasticity, lower limb
Mri brain other abnormalities
Spastic gait
Show more (+8)
n.a.
No
C
ITA
32
60
n.a.
Spastic gait
Central motor conduction time abnormality
Pes cavus
Babinski sign
Impaired vibratory sensation
Spasticity, lower limb
Show more (+3)
n.a.
No
C
ITA
41
66
n.a.
Spastic gait
Nerve conduction studies other abnormalities
Abnormality of the bladder
Babinski sign
Walking aids
Spasticity, lower limb
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Mri brain other abnormalities
Show more (+7)
n.a.
No
C
ITA
26
49
n.a.
Spasticity, lower limb
Babinski sign
Pes cavus
Impaired vibratory sensation
Spastic gait
Abnormality of the bladder
Central motor conduction time abnormality
Show more (+4)
n.a.
No
C
ITA
26
46
n.a.
Central motor conduction time abnormality
Impaired vibratory sensation
Spastic gait
Spasticity, lower limb
Babinski sign
Pes cavus
Show more (+3)
n.a.
No
C
ITA
52
59
n.a.
Walking aids
Spastic gait
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Peripheral neuropathy on nerve conduction studies
Babinski sign
Cognitive impairment
Abnormality of the bladder
Mri brain other abnormalities
Spasticity, lower limb
Show more (+7)
n.a.
No
C
ITA
48
57
n.a.
Babinski sign
Peripheral neuropathy on nerve conduction studies
Walking aids
Spastic gait
Central motor conduction time abnormality
Cognitive impairment
Nerve conduction studies other abnormalities
Spasticity, lower limb
Mri brain other abnormalities
Abnormality of the bladder
Show more (+7)
n.a.
No
C
ITA
48
72
n.a.
Peripheral neuropathy on nerve conduction studies
Abnormality of the bladder
Walking aids
Babinski sign
Cognitive impairment
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Spasticity, lower limb
Spastic gait
Mri brain other abnormalities
Show more (+7)
n.a.