Orlacchio, 2005: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
ITA
25
46
n.a.
Spastic gait
Babinski sign
Pes cavus
Impaired vibratory sensation
Central motor conduction time abnormality
Spasticity, lower limb
Show more (+3)
n.a.
No
C
ITA
23
41
n.a.
Abnormality of the bladder
Pes cavus
Spasticity, lower limb
Impaired vibratory sensation
Spastic gait
Central motor conduction time abnormality
Babinski sign
Show more (+4)
n.a.
No
C
ITA
49
75
n.a.
Abnormality of the bladder
Nerve conduction studies other abnormalities
Mri brain other abnormalities
Inability to walk
Babinski sign
Spastic gait
Cognitive impairment
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Wheelchair
Spasticity, lower limb
Show more (+8)
n.a.
No
C
ITA
32
60
n.a.
Spasticity, lower limb
Pes cavus
Spastic gait
Central motor conduction time abnormality
Impaired vibratory sensation
Babinski sign
Show more (+3)
n.a.
No
C
ITA
41
66
n.a.
Mri brain other abnormalities
Peripheral neuropathy on nerve conduction studies
Abnormality of the bladder
Nerve conduction studies other abnormalities
Central motor conduction time abnormality
Cognitive impairment
Babinski sign
Spasticity, lower limb
Walking aids
Spastic gait
Show more (+7)
n.a.
No
C
ITA
26
49
n.a.
Abnormality of the bladder
Central motor conduction time abnormality
Spasticity, lower limb
Spastic gait
Pes cavus
Impaired vibratory sensation
Babinski sign
Show more (+4)
n.a.
No
C
ITA
26
46
n.a.
Spasticity, lower limb
Spastic gait
Central motor conduction time abnormality
Pes cavus
Babinski sign
Impaired vibratory sensation
Show more (+3)
n.a.
No
C
ITA
52
59
n.a.
Central motor conduction time abnormality
Spastic gait
Nerve conduction studies other abnormalities
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Walking aids
Mri brain other abnormalities
Spasticity, lower limb
Abnormality of the bladder
Babinski sign
Show more (+7)
n.a.
No
C
ITA
48
57
n.a.
Walking aids
Abnormality of the bladder
Cognitive impairment
Mri brain other abnormalities
Spastic gait
Spasticity, lower limb
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Nerve conduction studies other abnormalities
Babinski sign
Show more (+7)
n.a.
No
C
ITA
48
72
n.a.
Central motor conduction time abnormality
Mri brain other abnormalities
Walking aids
Abnormality of the bladder
Babinski sign
Spastic gait
Cognitive impairment
Spasticity, lower limb
Peripheral neuropathy on nerve conduction studies
Nerve conduction studies other abnormalities
Show more (+7)
n.a.