Orlacchio, 2005: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
ITA
25
46
n.a.
Impaired vibratory sensation
Spasticity, lower limb
Babinski sign
Pes cavus
Spastic gait
Central motor conduction time abnormality
Show more (+3)
n.a.
No
C
ITA
23
41
n.a.
Central motor conduction time abnormality
Babinski sign
Spastic gait
Spasticity, lower limb
Abnormality of the bladder
Impaired vibratory sensation
Pes cavus
Show more (+4)
n.a.
No
C
ITA
49
75
n.a.
Peripheral neuropathy on nerve conduction studies
Spasticity, lower limb
Babinski sign
Abnormality of the bladder
Spastic gait
Mri brain other abnormalities
Nerve conduction studies other abnormalities
Cognitive impairment
Central motor conduction time abnormality
Inability to walk
Wheelchair
Show more (+8)
n.a.
No
C
ITA
32
60
n.a.
Spastic gait
Spasticity, lower limb
Pes cavus
Babinski sign
Central motor conduction time abnormality
Impaired vibratory sensation
Show more (+3)
n.a.
No
C
ITA
41
66
n.a.
Cognitive impairment
Spasticity, lower limb
Walking aids
Nerve conduction studies other abnormalities
Peripheral neuropathy on nerve conduction studies
Abnormality of the bladder
Babinski sign
Mri brain other abnormalities
Central motor conduction time abnormality
Spastic gait
Show more (+7)
n.a.
No
C
ITA
26
49
n.a.
Central motor conduction time abnormality
Babinski sign
Spastic gait
Impaired vibratory sensation
Spasticity, lower limb
Pes cavus
Abnormality of the bladder
Show more (+4)
n.a.
No
C
ITA
26
46
n.a.
Central motor conduction time abnormality
Babinski sign
Pes cavus
Impaired vibratory sensation
Spastic gait
Spasticity, lower limb
Show more (+3)
n.a.
No
C
ITA
52
59
n.a.
Babinski sign
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Walking aids
Cognitive impairment
Nerve conduction studies other abnormalities
Spasticity, lower limb
Abnormality of the bladder
Mri brain other abnormalities
Spastic gait
Show more (+7)
n.a.
No
C
ITA
48
57
n.a.
Spastic gait
Mri brain other abnormalities
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Walking aids
Abnormality of the bladder
Cognitive impairment
Nerve conduction studies other abnormalities
Spasticity, lower limb
Babinski sign
Show more (+7)
n.a.
No
C
ITA
48
72
n.a.
Walking aids
Mri brain other abnormalities
Nerve conduction studies other abnormalities
Central motor conduction time abnormality
Babinski sign
Cognitive impairment
Spastic gait
Spasticity, lower limb
Peripheral neuropathy on nerve conduction studies
Abnormality of the bladder
Show more (+7)
n.a.