Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Walking aids
-Lower limb amyotrophy Abnormality of the bladder Spasticity, lower limb Lower limb muscle weakness -Pure or uncomplicated Spastic gait Hyperreflexia in upper limbs Impaired vibratory sensation Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Babinski sign
Spastic gait Abnormality of the bladder Walking aids Spasticity, lower limb -Pure or uncomplicated Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Hyperreflexia in upper limbs
Spastic gait Lower limb muscle weakness Babinski sign Walking aids Spasticity, lower limb -Pure or uncomplicated Impaired vibratory sensation Abnormality of the bladder -Lower limb amyotrophy Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Wheelchair
Spasticity, lower limb Walking aids Hyperreflexia in upper limbs Lower limb muscle weakness Muscle weakness, upper limb -Pure or uncomplicated Spastic gait Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Muscle weakness, upper limb
Babinski sign Abnormality of the bladder Spastic gait Lower limb muscle weakness Hyperreflexia in upper limbs Wheelchair Walking aids Spasticity, lower limb Impaired vibratory sensation Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Lower limb muscle weakness
-Pure or uncomplicated Abnormality of the bladder Impaired vibratory sensation Walking aids Hyperreflexia in upper limbs Spasticity, lower limb Spastic gait Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Abnormality of the bladder
Walking aids Spastic gait Impaired vibratory sensation -Pure or uncomplicated Spasticity, lower limb Babinski sign Lower limb muscle weakness Hyperreflexia in upper limbs Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Spastic gait
-Pure or uncomplicated Hyperreflexia in upper limbs Spasticity, lower limb Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Ataxia, limb
Hyperreflexia in upper limbs Impaired vibratory sensation Lower limb muscle weakness Spasticity, upper limb Spastic gait Abnormality of the bladder Spasticity, lower limb Babinski sign Walking aids Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Hyperreflexia in upper limbs
Spasticity, lower limb Babinski sign -Pure or uncomplicated Walking aids Spastic gait Lower limb muscle weakness -Lower limb amyotrophy Show more (+5) |
n.a.
|