Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Walking aids
Spastic gait -Pure or uncomplicated Hyperreflexia in upper limbs Lower limb muscle weakness Impaired vibratory sensation Abnormality of the bladder -Lower limb amyotrophy Spasticity, lower limb Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
-Pure or uncomplicated
Abnormality of the bladder Walking aids Spasticity, lower limb Spastic gait Babinski sign Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Abnormality of the bladder
Hyperreflexia in upper limbs -Pure or uncomplicated Spastic gait -Lower limb amyotrophy Impaired vibratory sensation Walking aids Babinski sign Lower limb muscle weakness Spasticity, lower limb Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Spastic gait
Spasticity, lower limb Babinski sign -Pure or uncomplicated Lower limb muscle weakness Hyperreflexia in upper limbs Wheelchair Walking aids Muscle weakness, upper limb Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Spastic gait
Babinski sign Hyperreflexia in upper limbs Spasticity, lower limb Lower limb muscle weakness Muscle weakness, upper limb Impaired vibratory sensation Abnormality of the bladder Wheelchair Walking aids Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Impaired vibratory sensation
Spasticity, lower limb Spastic gait Babinski sign -Pure or uncomplicated Hyperreflexia in upper limbs Abnormality of the bladder Lower limb muscle weakness Walking aids Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Abnormality of the bladder
Hyperreflexia in upper limbs Walking aids Lower limb muscle weakness Spasticity, lower limb Babinski sign Spastic gait Impaired vibratory sensation -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
-Pure or uncomplicated
Spasticity, lower limb Spastic gait Hyperreflexia in upper limbs Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Impaired vibratory sensation
Ataxia, limb Walking aids Lower limb muscle weakness Spastic gait Abnormality of the bladder Spasticity, lower limb Babinski sign Spasticity, upper limb Hyperreflexia in upper limbs Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Spasticity, lower limb
Lower limb muscle weakness -Lower limb amyotrophy Babinski sign -Pure or uncomplicated Hyperreflexia in upper limbs Walking aids Spastic gait Show more (+5) |
n.a.
|