Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Spasticity, lower limb
-Pure or uncomplicated Lower limb muscle weakness Impaired vibratory sensation Abnormality of the bladder Hyperreflexia in upper limbs Walking aids -Lower limb amyotrophy Spastic gait Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
-Pure or uncomplicated
Walking aids Abnormality of the bladder Babinski sign Spasticity, lower limb Spastic gait Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
-Pure or uncomplicated
Lower limb muscle weakness Abnormality of the bladder Hyperreflexia in upper limbs Babinski sign Spasticity, lower limb Impaired vibratory sensation Walking aids -Lower limb amyotrophy Spastic gait Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Walking aids
Hyperreflexia in upper limbs -Pure or uncomplicated Spastic gait Wheelchair Babinski sign Lower limb muscle weakness Muscle weakness, upper limb Spasticity, lower limb Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Muscle weakness, upper limb
Abnormality of the bladder Hyperreflexia in upper limbs Walking aids Spasticity, lower limb Wheelchair Babinski sign Spastic gait Impaired vibratory sensation Lower limb muscle weakness Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Babinski sign
-Pure or uncomplicated Spastic gait Impaired vibratory sensation Walking aids Abnormality of the bladder Lower limb muscle weakness Spasticity, lower limb Hyperreflexia in upper limbs Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
-Pure or uncomplicated
Spastic gait Babinski sign Hyperreflexia in upper limbs Lower limb muscle weakness Spasticity, lower limb Impaired vibratory sensation Walking aids Abnormality of the bladder Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
-Pure or uncomplicated
Spasticity, lower limb Spastic gait Hyperreflexia in upper limbs Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Lower limb muscle weakness
Spastic gait Babinski sign Spasticity, lower limb Ataxia, limb Impaired vibratory sensation Spasticity, upper limb Walking aids Hyperreflexia in upper limbs Abnormality of the bladder Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Hyperreflexia in upper limbs
Lower limb muscle weakness -Pure or uncomplicated Babinski sign Spasticity, lower limb Spastic gait -Lower limb amyotrophy Walking aids Show more (+5) |
n.a.
|