Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Abnormality of the bladder
Hyperreflexia in upper limbs Walking aids Impaired vibratory sensation -Pure or uncomplicated Spasticity, lower limb -Lower limb amyotrophy Lower limb muscle weakness Spastic gait Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Walking aids
Spastic gait -Pure or uncomplicated Abnormality of the bladder Spasticity, lower limb Babinski sign Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Abnormality of the bladder
Babinski sign Lower limb muscle weakness Hyperreflexia in upper limbs Spastic gait -Lower limb amyotrophy -Pure or uncomplicated Spasticity, lower limb Impaired vibratory sensation Walking aids Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Spasticity, lower limb
Hyperreflexia in upper limbs Wheelchair Walking aids Spastic gait -Pure or uncomplicated Lower limb muscle weakness Babinski sign Muscle weakness, upper limb Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Lower limb muscle weakness
Spastic gait Babinski sign Walking aids Spasticity, lower limb Impaired vibratory sensation Abnormality of the bladder Muscle weakness, upper limb Hyperreflexia in upper limbs Wheelchair Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Walking aids
Abnormality of the bladder Spasticity, lower limb Babinski sign Impaired vibratory sensation Spastic gait Hyperreflexia in upper limbs -Pure or uncomplicated Lower limb muscle weakness Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
-Pure or uncomplicated
Impaired vibratory sensation Babinski sign Abnormality of the bladder Spastic gait Lower limb muscle weakness Hyperreflexia in upper limbs Spasticity, lower limb Walking aids Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Hyperreflexia in upper limbs
-Pure or uncomplicated Spastic gait Spasticity, lower limb Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Spastic gait
Abnormality of the bladder Spasticity, upper limb Spasticity, lower limb Impaired vibratory sensation Hyperreflexia in upper limbs Lower limb muscle weakness Walking aids Ataxia, limb Babinski sign Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Babinski sign
-Lower limb amyotrophy -Pure or uncomplicated Walking aids Hyperreflexia in upper limbs Spasticity, lower limb Lower limb muscle weakness Spastic gait Show more (+5) |
n.a.
|