Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Lower limb muscle weakness
-Pure or uncomplicated Spastic gait -Lower limb amyotrophy Spasticity, lower limb Abnormality of the bladder Hyperreflexia in upper limbs Walking aids Impaired vibratory sensation Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
-Pure or uncomplicated
Spastic gait Babinski sign Spasticity, lower limb Walking aids Abnormality of the bladder Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
-Lower limb amyotrophy
Babinski sign -Pure or uncomplicated Abnormality of the bladder Spasticity, lower limb Impaired vibratory sensation Lower limb muscle weakness Hyperreflexia in upper limbs Walking aids Spastic gait Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Lower limb muscle weakness
-Pure or uncomplicated Muscle weakness, upper limb Babinski sign Hyperreflexia in upper limbs Spastic gait Spasticity, lower limb Wheelchair Walking aids Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Impaired vibratory sensation
Babinski sign Walking aids Spastic gait Muscle weakness, upper limb Spasticity, lower limb Abnormality of the bladder Wheelchair Hyperreflexia in upper limbs Lower limb muscle weakness Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Babinski sign
Impaired vibratory sensation Spasticity, lower limb Walking aids Abnormality of the bladder Lower limb muscle weakness Hyperreflexia in upper limbs Spastic gait -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Walking aids
Lower limb muscle weakness Impaired vibratory sensation Spastic gait -Pure or uncomplicated Babinski sign Spasticity, lower limb Hyperreflexia in upper limbs Abnormality of the bladder Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Spastic gait
-Pure or uncomplicated Spasticity, lower limb Hyperreflexia in upper limbs Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Spastic gait
Spasticity, upper limb Babinski sign Impaired vibratory sensation Hyperreflexia in upper limbs Abnormality of the bladder Lower limb muscle weakness Ataxia, limb Walking aids Spasticity, lower limb Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Hyperreflexia in upper limbs
Babinski sign Spasticity, lower limb -Pure or uncomplicated Walking aids -Lower limb amyotrophy Spastic gait Lower limb muscle weakness Show more (+5) |
n.a.
|