Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Spasticity, lower limb
Abnormality of the bladder -Pure or uncomplicated Impaired vibratory sensation Lower limb muscle weakness Walking aids -Lower limb amyotrophy Hyperreflexia in upper limbs Spastic gait Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Spastic gait
Spasticity, lower limb -Pure or uncomplicated Walking aids Abnormality of the bladder Babinski sign Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Walking aids
Spastic gait -Lower limb amyotrophy Abnormality of the bladder Hyperreflexia in upper limbs Impaired vibratory sensation Lower limb muscle weakness -Pure or uncomplicated Spasticity, lower limb Babinski sign Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Spasticity, lower limb
Lower limb muscle weakness Spastic gait Hyperreflexia in upper limbs Babinski sign Wheelchair Walking aids Muscle weakness, upper limb -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Impaired vibratory sensation
Hyperreflexia in upper limbs Muscle weakness, upper limb Spasticity, lower limb Walking aids Spastic gait Lower limb muscle weakness Babinski sign Abnormality of the bladder Wheelchair Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Spasticity, lower limb
Lower limb muscle weakness Abnormality of the bladder Walking aids Babinski sign Hyperreflexia in upper limbs Impaired vibratory sensation Spastic gait -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Lower limb muscle weakness
Hyperreflexia in upper limbs Spastic gait Walking aids Abnormality of the bladder Impaired vibratory sensation Babinski sign Spasticity, lower limb -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
-Pure or uncomplicated
Spastic gait Spasticity, lower limb Hyperreflexia in upper limbs Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Impaired vibratory sensation
Ataxia, limb Lower limb muscle weakness Babinski sign Spasticity, upper limb Walking aids Spastic gait Spasticity, lower limb Hyperreflexia in upper limbs Abnormality of the bladder Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Walking aids
-Lower limb amyotrophy Spasticity, lower limb Hyperreflexia in upper limbs Babinski sign Lower limb muscle weakness Spastic gait -Pure or uncomplicated Show more (+5) |
n.a.
|