Vandebona, 2012: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
O
AUS
25
n.a.
n.a.
Walking aids
Spastic gait
-Pure or uncomplicated
Hyperreflexia in upper limbs
Lower limb muscle weakness
Impaired vibratory sensation
Abnormality of the bladder
-Lower limb amyotrophy
Spasticity, lower limb
Show more (+6)
n.a.
Yes
n.a.
O
AUS
20
54
n.a.
-Pure or uncomplicated
Abnormality of the bladder
Walking aids
Spasticity, lower limb
Spastic gait
Babinski sign
Show more (+3)
n.a.
Yes
n.a.
O
AUS
4
73
n.a.
Abnormality of the bladder
Hyperreflexia in upper limbs
-Pure or uncomplicated
Spastic gait
-Lower limb amyotrophy
Impaired vibratory sensation
Walking aids
Babinski sign
Lower limb muscle weakness
Spasticity, lower limb
Show more (+7)
n.a.
p.Trp148*: het
Yes
n.a.
O
AUS
41
65
n.a.
Spastic gait
Spasticity, lower limb
Babinski sign
-Pure or uncomplicated
Lower limb muscle weakness
Hyperreflexia in upper limbs
Wheelchair
Walking aids
Muscle weakness, upper limb
Show more (+6)
n.a.
Yes
n.a.
O
AUS
2
48
n.a.
Spastic gait
Babinski sign
Hyperreflexia in upper limbs
Spasticity, lower limb
Lower limb muscle weakness
Muscle weakness, upper limb
Impaired vibratory sensation
Abnormality of the bladder
Wheelchair
Walking aids
Show more (+7)
n.a.
Yes
n.a.
O
AUS
2
60
n.a.
Impaired vibratory sensation
Spasticity, lower limb
Spastic gait
Babinski sign
-Pure or uncomplicated
Hyperreflexia in upper limbs
Abnormality of the bladder
Lower limb muscle weakness
Walking aids
Show more (+6)
n.a.
Yes
n.a.
O
AUS
n.a.
55
n.a.
Abnormality of the bladder
Hyperreflexia in upper limbs
Walking aids
Lower limb muscle weakness
Spasticity, lower limb
Babinski sign
Spastic gait
Impaired vibratory sensation
-Pure or uncomplicated
Show more (+6)
n.a.
Yes
n.a.
O
AUS
32
38
n.a.
-Pure or uncomplicated
Spasticity, lower limb
Spastic gait
Hyperreflexia in upper limbs
Show more (+1)
n.a.
Yes
n.a.
O
AUS
10
48
n.a.
Impaired vibratory sensation
Ataxia, limb
Walking aids
Lower limb muscle weakness
Spastic gait
Abnormality of the bladder
Spasticity, lower limb
Babinski sign
Spasticity, upper limb
Hyperreflexia in upper limbs
Show more (+7)
n.a.
Yes
n.a.
O
AUS
n.a.
n.a.
n.a.
Spasticity, lower limb
Lower limb muscle weakness
-Lower limb amyotrophy
Babinski sign
-Pure or uncomplicated
Hyperreflexia in upper limbs
Walking aids
Spastic gait
Show more (+5)
n.a.