Nielsen, 2004: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
No
C
DNK
60
79
n.a.
Babinski sign
Gait ataxia
Spasticity, lower limb
Dysarthria
Lower limb muscle weakness
Cognitive impairment
Wheelchair
Nystagmus
Spastic gait
Inability to walk
Cerebellar atrophy
Ataxia, limb
Show more (+9)
n.a.
p.Gln490*: het
No
C
DNK
25
39
n.a.
Abnormality of the bladder
Spasticity, lower limb
Cerebellar atrophy
Dysarthria
Gait ataxia
Ataxia, limb
Babinski sign
Spastic gait
Show more (+5)
n.a.
p.Gln490*: het
No
C
DNK
n.a.
81
n.a.
Hyperreflexia in upper limbs
Lower limb muscle weakness
Muscle weakness, upper limb
Inability to walk
Wheelchair
Spasticity, lower limb
Show more (+3)
n.a.
p.Gln490*: het
Yes
C
DNK
30
44
n.a.
Lower limb muscle weakness
Ataxia, limb
Babinski sign
Hyperreflexia in upper limbs
Dysarthria
-Lower limb amyotrophy
Seizures
Nystagmus
Cerebellar atrophy
Spasticity, lower limb
Show more (+7)
n.a.
p.Gln490*: het
No
C
DNK
7
43
n.a.
Nystagmus
Spasticity, lower limb
Abnormality of the bladder
Impaired vibratory sensation
Dysarthria
Babinski sign
Ataxia, limb
Lower limb muscle weakness
Hyperreflexia in upper limbs
Show more (+6)
n.a.
p.Gln490*: het