Bertelli, 2006: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
ITA
30
66
n.a.
Central motor conduction time abnormality
Spasticity, lower limb
Pes cavus
Upper limb amyotrophy
Babinski sign
Mri brain other abnormalities
Spastic gait
-Pure or uncomplicated
Lower limb muscle weakness
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n.a.
Yes
C
ITA
20
40
n.a.
Lower limb muscle weakness
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Global developmental delay
Spasticity, lower limb
Babinski sign
Abnormality of the cerebral white matter
Nerve conduction studies other abnormalities
Central motor conduction time abnormality
Spastic gait
Seizures
Mri brain other abnormalities
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n.a.